5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT), as well as one species of toad. 5-MeO-DMT can also be synthetically produced.
In Central and South America, 5-MeO-DMT is most often sourced from Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff. It’s also found in the milky white venom of the Colorado River Toad (Bufo alvarius/Incilius alvarius), which is native to the southwestern United States and northwestern Mexico.
This isn’t the psychedelic you remember from college. It isn’t an eight-hour marathon experience tripping through the woods like Alice. It’s fast-acting, short-duration — sometimes lasting as briefly as seven minutes — and is a rocket-ship ride into the center of the cosmos. In a recent European study, after one single use, the substance 5-MeO-DMT was shown to produce sustained enhancement of satisfaction with life, and easing of anxiety, depression and post-traumatic stress disorder (PTSD).
When former heavyweight boxing champion Mike Tyson first tried 5-MeO-DMT — also called “the toad” — he said it knocked him off his feet, profoundly changing his life. “I came across this thing called the toad. I smoked this medicine, drug, whatever you want to call it, and I’ve never been the same,” Tyson said on the Joe Rogan Experience podcast last year, viewed by nearly 10 million people. “I look at life differently, I look at people differently. It’s almost like dying and being reborn… It’s inconceivable. I tried to explain it to some people, to my wife, I don’t have the words to explain it. It’s almost like you’re dying, you’re submissive, you’re humble, you’re vulnerable — but you’re invincible still in all.”
One single 50mg vaporized dose — derived from dried venom secreted by the Bufo alvarius toad — often produces hallucinogenic, boundless experiences within one second of inhalation that can last from 7 to 90 minutes, and on average lasts 20 minutes. Like Tyson, people report mystical experiences, many “seeing God,” and often sensing a better understanding of their place and function in the cosmos as a result. Shortly after use, participants tend to be totally clearheaded and 100% back to their previous ordinary state.